News Archive

11/01/2010. There is an increasing demand from the pharmaceutical and biotechnology industries for methods to replace the use of animals in drug testing. Dr Gwen Reilly’s team at the University of Sheffield are leaders in the investigation of culture methods for growth of bone cells in 3D. These methods are used as in vitro models and provide alternatives to animal experiments in orthopaedic research.

Dr Reilly has secured funding to work with Orla on the development and trial of novel in vitro cell culture products, via two project grants awarded by METRC: the N8 Molecular Engineering Translational Research Centre.

Dr Reilly’s group will investigate surfaces coated with Orla’s bio-active proteins to accelerate the differentiation of human mesenchymal stem cells (MSC’s) to produce high quality ‘bone-like’ material. MSC’s will be grown serum-free on a selection of Orla scaffolds, including modified gold, glass and polyester matrices which have been coated with proteins predicted to be suitable for MSC differentiation and bone formation.

Bone in vivo is subjected to continuous perfusion of fluid via the blood system. In a second, short term project, an Orla 3D Cell Carrier TM will be used in a fluid-flow bioreactor to investigate bone growth under ‘life-like’ conditions.

11/11/2009
Launch of OJ-Bio

11/10/2009
Orla attending UK Nanoforum 2009

09/09/2009
Orla has moved

08/08/2009
Orla Biosurfaces featured in Materials today

24/06/2009
Orla attending ISSCR 2009 in Barcelona

03/04/2009
Orla to attend UKNSCN 2009 meeting in Oxford

01/01/2009
Orla attending Nanotech 2009 in Tokyo

23/09/2008
Omron present data using Orla Technology

19/09/2008
Orla benefit from latest Technology Strategy Board funding

19/08/2008
Orla presenting at Advamed 2008

07/07/2008
Orla student presenting at Gordon Conference

13/05/2008
Orla to attend ISSCR 2008